Over the past 30 years, tremendous advances in imaging technology have provided researchers with the means to acquire and analyze detailed images of biological specimens. Imaging is now an essential tool for the researcher who investigates the cellular and biochemical processes underlying cellular function. From the simple analysis of fluorescent intensity to the more sophisticated methods to classify and quantify cells in different stages of the cell cycle, imaging is fundamental to research microscopy.

The MetaMorph Software suite of products from Molecular Devices has been an integral part of the bioresearch imaging community for more than 25 years and supports a vast array of microscopes, cameras, and precision stages. The extensive suite of software provides acquisition, processing, and analysis features that allow researchers to build custom imaging systems for solving novel experimental problems in cellular imaging.

Please use the links below to learn more about how we can support the success of your bio analytical and research imaging efforts.

Combine ease-of-use & flexibility to accommodate automated image analysis for hundreds of applications in both research and high throughput environments.

A modular toolbox for image analysis, the suite of MetaMorph Software Application Modules enable both novice and expert users to set up hundreds of assays in minutes without compromising the mature image processing algorithms required to address complex applications. The Application Modules provide an interactive environment to determine features of interest based on size, intensities, and distances. Some modules handle very specific and challenging assays (e.g., neurite outgrowth) while others (e.g., multi-wavelength cell scoring) can be configured to quantify dozen of different cellular events. To further tailor analysis to your research-oriented goals, journals can be amended to Application Modules, allowing to customize any analysis.

12 Application Modules allow MetaMorph Software users to automate common analysis routines and accommodate 100's of applications.

• 12 Application Modules allow MetaMorph Software users to automate common analysis routines and accommodate 100's of applications (see the applications tab).
• Interactive Environment guides users through the determination of features of interest.

The Count Nuclei Application module guides user through selection of segmentation parameters and output measurements yielding accurate results even in the presence of background shading and closely spaced cells.

• Adaptive Background Correction mitigates poor sample quality while improving image segmentation.

All MetaXpress Software Application Modules are equipped with an adaptive background correction algorithm to mitigate poor sample quality while improving image segmentation. (Left) Unevenly stained sample before segmentation (Center) after conventional segmentation, some of the features are not identified (Right) with Adaptive Background Correction, all the features are identified.

• Field-by-Field Data, Cell-by-Cell Data, and Segmentation Overlays are made available to ensure in-depth downstream analysis such as gating cell populations or reviewing accuracy of segmentation.

  Field-by-field (summary) data, cell-by-cell (cellular) data, and segmentation overlays are made available to ensure in-depth downstream analysis.

• Customization of Application Modules for research and assay development can easily be achieved by amending journals to Application Modules (Note: the resulting analysis will not be compatible with analysis with the MetaXpress PowerCore Software).

• Windows XP, Windows Vista, or Windows 7 required.
• MetaMorph Software runs under 32-bit and 64-bit operating systems. Please note, not all hardware drivers are compatible with 64-bit systems.
• Recommended computer specification

• Dual core processor or better
• 4 GB of RAM or more
• 500 GB SATA hard drive
• 320 MB EVGA GeForce Video Card
• 1 LPT port
• 6 integrated USB 2.0 ports
• 2 integrated FireWire ports
• 2 serial ports
• 3 available PCI slots
• 10/100/1000 MBps Gigabit network adapter
• DVD+/RW/CD-RW
• 550W power supply

Compatible products from Molecular Devices:

• Complete integration with MetaMorph Microscopy Automation and Image Analysis Software.
• Seamless file sharing and analysis with MetaXpress High Content Analysis Software
• Analyzes data directly from ImageXpress Micro and ImageXpress Ultra High Content Screening Systems.